| Prevalence | 0.5-1% of population, higher in elderly |
| Mammillary body damage | Necrosis and gliosis in the mammillary bodies, particularly the medial nuclei |
| Thalamic lesions | Damage to the mediodorsal thalamic nuclei |
| Fornix injury | Degeneration of fornix white matter |
| Pyruvate dehydrogenase | Converts pyruvate to acetyl-CoA for energy metabolism |
| Alpha-ketoglutarate dehydrogenase | Critical for Krebs cycle function |
| Transketolase | Pentose phosphate pathway enzyme |
| Apraxia | Difficulty with purposeful movements |
| Agraphia | Impaired writing ability |
| Acalculia | Difficulty with calculations |
| Visuospatial deficits | Problems with spatial awareness |
| Lack of insight | Reduced awareness of memory deficits |
| Databases | OMIMOrphanetClinicalTrialsPubMed |