Contents

Pain in Corticobasal Syndrome

Disease Info

Disease duration	Pain often develops within the first 2-3 years of symptom onset, though it may precede the diagnosis
Motor phenotype	Patients with prominent dystonia and rigidity are more likely to experience pain
Underlying pathology	CBD pathology is more strongly associated with pain than PSP pathology when presenting as CBS[@clinical2020]
Age	Younger onset age may be associated with higher pain prevalence
Thalamic dysfunction	The thalamus serves as a critical relay for pain signals. Thalamic neurodegeneration in CBS may disrupt normal pain processing, leading to hyperexcitability
Cortical hyperexcitability	Motor cortex involvement in CBS extends to sensory processing areas, altering pain thresholds
Basal ganglia modulation	The basal ganglia participate in pain perception and modulation through connections with the thalamus and cortex
Databases	OMIM Orphanet ClinicalTrials PubMed

Knowledge Graph