disease 2,120 words KG: ent-dise-7fe78ca5 2026-03-22
kind:diseasesection:diseasesstate:published
Contents

Paraneoplastic Neurological Syndromes

Disease Info
Lower-risk antibodiesanti-NMDAR (except in teratoma), anti-LGI1, anti-GABA-B
Anti-Yo (PCA-1)Most common; associated with ovarian cancer and breast cancer. Targets cerebellar degeneration-related protein 2 (CDR2) and CDR2L in Purkinje cells
Anti-Tr/DNERAssociated with Hodgkin lymphoma. Targets Delta/Notch-like EGF-related receptor on Purkinje cells
Anti-Hu (ANNA-1)Associated with small cell lung cancer (SCLC). Usually presents as part of multifocal encephalomyelitis with cerebellar involvement
Anti-VGCCAssociated with SCLC, often co-occurring with Lambert-Eaton syndrome
Anti-mGluR1Associated with Hodgkin lymphoma
Anti-HuSCLC (most common paraneoplastic cause of limbic encephalitis)
Anti-Ma2Testicular germ cell tumors (young males), lung cancer (older patients)
Anti-AMPARBreast, lung, thymic tumors
Anti-GABA-BSCLC
Anti-CASPR2Thymoma (also occurs without cancer)
DatabasesOMIMOrphanetClinicalTrialsPubMed

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