disease 1,182 words KG: ent-dise-7b64c99a 2026-03-21
kind:diseasesection:diseasesstate:published
Contents

Pure Akinesia with Gait Freezing

Disease Info
PrevalenceRare; estimated 1-5% of parkinsonian disorders
Age of onsetTypically 60-75 years
ProgressionSlowly progressive over 5-15 years
Sex distributionSlight male predominance reported in some series
Freezing of Gait (FOG)Sudden, episodic inability to step forward
AkinesiaReduced spontaneous movements, particularly in the lower extremities
Start HesitationMarked difficulty initiating the first step
Turn-FreezingFreezing specifically when attempting to turn
FestinationProgressive shortening of steps during walking
Postural instabilityFrequent falls, often backward
Reduced arm swingBilateral rather than unilateral
Facial maskingReduced facial expression
DatabasesOMIMOrphanetClinicalTrialsPubMed

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