disease 1,398 words KG: ent-dise-f3f224f4 2026-03-20
kind:diseasesection:diseasesstate:published
Contents

Walker-Warburg Syndrome

Disease Info
FUT8Fucose transporter, recently implicated in some WWS cases.
Cerebellar hypoplasiaUnderdevelopment of the cerebellum, particularly the vermis, contributing to ataxia and motor dysfunction.
VentriculomegalyEnlargement of the cerebral ventricles, often due to obstruction of cerebrospinal fluid flow.
Corpus callosum agenesisPartial or complete absence of the corpus callosum connecting the cerebral hemispheres.
Brainstem abnormalitiesIncluding hypoplasia of the pons and medulla.
Severe hypotoniaFloppy infant appearance from birth
Poor motor developmentFailure to achieve milestones like head control
Feeding difficultiesRequiring nutritional support
Respiratory distressDue to weak respiratory muscles
Profound intellectual disabilityMost surviving children have severe cognitive impairment
DatabasesOMIMOrphanetClinicalTrialsPubMed

Knowledge Graph