| Oligodendrocyte inclusions | Coil-shaped inclusions and globose tangles within oligodendrocytes disrupt myelin production and maintenance[^1] |
| Axonal tau accumulation | Tau-laden axons show reduced axonal transport capacity, leading to Wallerian-like degeneration[^2] |
| Myelin breakdown | Secondary demyelination accompanies axonal loss, compounding white matter signal changes on MRI |
| Pyramidal decussation | Asymmetric involvement at the level of the internal capsule and cerebral peduncle |
| Brainstem | Significant reduction in fractional anisotropy (FA) within the basis pontis |
| Spinal cord | Cord atrophy correlates with clinical bradykinesia scores |
| Genu | Early involvement affecting interhemispheric prefrontal connections |
| Body | Mid-callosal atrophy correlates with interlimb apraxia severity |
| Isthmus | Posterior callosal damage associated with visuospatial deficits |
| Thalamic radiations | Anterior thalamic radiations show reduced FA, correlating with executive dysfunction |
| Striatal connections | Loss of integrity in connections to the caudate and putamen |
| Frontostriatal loops | Disconnection contributes to bradykinesia and rigidity |
| Databases | OMIMOrphanetClinicalTrialsPubMed |