mechanism 2,255 words KG: ent-gene-232ff3f5 2026-04-01

kind:mechanism section:mechanisms evidence:strong state:published topic:causal-chains topic:endocytosis topic:amyloid topic:alzheimers topic:genetics

Contents

PICALM→Clathrin-Mediated Endocytosis→Aβ Accumulation→AD Causal Chain

🔬 Protein Info

Gene Symbol	PICALM (CALM, CLT)
Chromosome	10q24.2
Exons	21
UniProt ID	Q7Z417
NCBI Gene ID	81501
Ensembl ID	ENSG00000021762
OMIM	610004
Transcript Length	~3.8 kb (mRNA), 652 amino acids (protein)
Databases	GeneCards HPA STRING

Knowledge Graph