| Cortical dysfunction | from parietal, premotor, and supplementary motor area involvement |
| Basal ganglia impairment | affecting saccade selection and initiation |
| Brainstem integration deficits | faulty sensorimotor transformation |
| Cerebellar contributions | affecting smooth pursuit and saccade accuracy |
| CBS | Normal or near-normal saccade velocity |
| PSP | Markedly reduced vertical saccade velocity (the hallmark finding) |
| Cerebellar involvement | flocculus and paraflocculus dysfunction |
| Parietal lobe contributions | impaired visual motion processing |
| Reduced blink rate | contributing to corneal exposure |
| Impaired convergence | especially with parietal involvement |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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