| Prevalence | Approximately 1 in 1,000,000 individuals |
| Typical Onset | Highly variable (2nd to 7th decade), typically in middle age |
| Inheritance | Autosomal dominant (most cases); sporadic cases also reported |
| Full Name | Fahr's Disease / Idiopathic Familial Cerebral Ferrocalcinosis |
| Synonyms | Fahr's syndrome, Striopallidodentate calcinosis, Cerebrotendinous calcification |
| Classification | Neurodegeneration with Brain Iron Accumulation (NBIA) / Movement Disorder / Neurogenetic Disorder |
| ICD-10 Code | G23.8 (Other degenerative diseases of basal ganglia) |
| Gender Distribution | Slight male predominance reported in some studies |
| SLC20A2 mutations | Impair phosphate transport, leading to abnormal calcium/iron deposition[@roubergue2013] |
| PDGFRB mutations | Affect vascular integrity and mineral metabolism[@baker2014] |
| PLCB4 mutations | Disrupt cellular signaling pathways |
| Parkinsonism | Bradykinesia, rigidity, tremor |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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