| Gene Symbol | ATP2B2 |
| Full Name | ATPase Plasma Membrane Ca2+ Transporting 2 |
| Chromosome | 3p25.3 |
| Protein Type | Transporter |
| Function | ATP2B2 (PMCA2) is a plasma membrane calcium ATPase important for auditory function and synaptic plasticity. |
| Primary Expression | the inner ear and brain |
| Subcellular Localization | the plasma membrane and interacts with calmodulin, which acts as a regulatory cofactor. Calmodulin binding increases the |
| UniProt ID | [Q9UQC2](https://www.uniprot.org/uniprotkb/Q9UQC2/entry) |
| GeneCards | ATP2B2 |
| Human Protein Atlas | ATP2B2 |
| ATP2A | Sarcoplasmic reticulum calcium ATPase genes involved in calcium signaling |
| CALMODULIN | Key regulatory protein for PMCA2 activation |
| SLC8A3 | Sodium-calcium exchanger contributing to neuronal calcium homeostasis |
| Calcium Dysregulation | Central pathology in multiple neurodegenerative diseases |
| Associated Diseases | Deafness, cerebellar ataxia |
| Databases | GeneCardsNCBI GeneHPASTRING |
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