| Gene Symbol | BAG4 |
| Chromosome | 8p11.21 |
| Protein Type | Chaperone |
| Function | is a member of the BAG family of co-chaperones that modulate the activity of Hsp70/Hsc70 heat shock proteins. |
| Amino Acids | 110 aa |
| Ensembl ID | ENSG00000140650 |
| GeneCards | BAG4 |
| Human Protein Atlas | BAG4 |
| Hsp70 Co-chaperone Activity | Binds to Hsp70 ATPase domain, modulating its chaperone cycle |
| Anti-apoptotic Function | Inhibits apoptosis through multiple mechanisms |
| Protein Quality Control | Facilitates refolding and clearance of damaged proteins |
| Tumor Suppressor Activity | Frequently downregulated in cancers, suggesting tumor suppressive function |
| [HSP70 family](/proteins/hsp70-protein) | Hsp70/Hsc70 ATP-dependent chaperone |
| [HSP40 family](/proteins/hsp40-protein) | Hsp40 co-chapERones that stimulate Hsp70 ATPase |
| [HSP90 family](/entities/hsp90-protein) | Hsp90 chaperone complex |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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