| Gene Symbol | BRSK1 |
| Full Name | Brain-Specific Serine/Threonine-Protein Kinase 1 |
| Chromosome | 19q13.42 |
| Protein Type | Serine/Threonine Kinase |
| Function | BRSK1 is a brain-enriched serine/threonine kinase essential for neuronal polarization and axon specification |
| Subcellular Localization | **Calcium regulation** — BRSK1 activity may be modulated by calcium-dependent signaling in neurons |
| Pathways | AMPK |
| UniProt ID | Q8TDC3 |
| NCBI Gene ID | 84446 |
| Ensembl ID | ENSG00000160469 |
| OMIM | 609235 |
| GeneCards | BRSK1 |
| Human Protein Atlas | BRSK1 |
| Axon determination | BRSK1 is activated by LKB1/STK11 at the nascent axon tip; its local activation triggers the symmetry-breaking event that converts one neurite into the axon |
| SAD kinase function | In *C. elegans*, the SAD-1 ortholog clusters synaptic vesicles at presynaptic terminals; mammalian BRSK1 retains this function while gaining additional polarity roles |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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