Contents

C8A

🧬 Gene Info

Gene Symbol	C8A
Chromosome	1p31.3
Function	The C8 alpha chain functions as
Amino Acids	579 aa
Ensembl ID	ENSG00000157216
GeneCards	C8A
Human Protein Atlas	C8A
C8 Deficiency	Individuals with C8 deficiency have increased susceptibility to Neisseria infections, particularly Neisseria meningitidis
Recurrent Infections	Lack of functional MAC leads to impaired bacterial killing
MAC-mediated Injury	Sublytic MAC formation can contribute to neuronal injury in various neurodegenerative conditions
Glial Activation	MAC deposition may activate glial cells and contribute to neuroinflammation
Liver	Primary site of synthesis (hepatocytes)
Brain	Low baseline expression in astrocytes and microglia
Various tissues	Widely expressed at low levels
Diagnostic Markers	C8 levels can be measured for complement deficiency workup
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

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