| Gene Symbol | CACNG8 |
| Chromosome | 11q13.1 |
| Function | ### Synaptic Transmission |
| Primary Expression | the hippocampus and cerebral cortex, where it plays crucial roles in synaptic transmission, lea |
| Amino Acids | 322 aa |
| Exons | 14 |
| Ensembl ID | ENSG00000167528 |
| GeneCards | CACNG8 |
| Human Protein Atlas | CACNG8 |
| AMPA receptor regulation | TARP γ8 dramatically slows deactivation and desensitization kinetics of AMPA receptors, prolonging synaptic currents[@kraft2016] |
| Trafficking | TARP γ8 is required for proper delivery of AMPA receptors to synaptic sites during development and plasticity |
| gating modulation | TARP γ8 stabilizes the open state of AMPA receptors, enhancing synaptic efficacy |
| Impaired AMPA receptor regulation | Reduced TARP γ8 expression in AD hippocampus correlates with synaptic failure[@tarps2009] |
| Calcium dysregulation | Altered calcium channel function affects synaptic plasticity |
| Memory deficits | TARP γ8-dependent mechanisms are essential for hippocampal memory consolidation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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