| Gene Symbol | CCNL1 |
| Aliases | Cyclin L1 gene |
| Function | The CCNL1 gene encodes Cyclin L1, a 646-amino acid protein |
| Primary Expression | human tissues with highest expression in brain, heart, and testis |
| Subcellular Localization | s and functions. Expression is regulated during cell cycle and in response to cellular stress |
| Amino Acids | 646 aa |
| UniProt ID | CCNL1 |
| Ensembl ID | ENSG00000132359 |
| GeneCards | CCNL1 |
| Human Protein Atlas | CCNL1 |
| Pre-mRNA Splicing | Essential component of the spliceosome, regulating both constitutive and alternative splicing. |
| Transcriptional Regulation | Partners with CDK11 to phosphorylate RNA polymerase II and transcriptional co-activators. |
| Alternative Splicing | The RS domain allows interaction with splicing factors to modulate splice site selection. |
| Cell Cycle Control | Regulates G2/M transition through phosphorylation of cell cycle targets. |
| Cancer | CCNL1 overexpression in various cancers including lung, breast, and ovarian cancers. Promotes tumor growth through enhanced splicing of oncogenic isoforms. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |