| Gene Symbol | CHRNA1 |
| Full Name | Cholinergic Receptor Nicotinic Alpha Subunit 1 |
| Chromosome | 2q31.1 |
| Function | CHRNA1 is a key component of the muscle-type nAChR, a pentameric ligand-gated ion channel[@changeux2020]: |
| Molecular Weight | 55 kDa |
| UniProt ID | P30530 |
| NCBI Gene ID | 1135 |
| Ensembl ID | ENSG00000138435 |
| OMIM | 100710 |
| GeneCards | CHRNA1 |
| Human Protein Atlas | CHRNA1 |
| ACh Binding | The alpha-1 subunit contains the primary acetylcholine binding site |
| Ion Channel | Forms the cation-permeable pore for Na⁺ and K⁺ influx |
| Endplate Potential | Triggers muscle fiber depolarization at the NMJ |
| Pentameric Assembly | Typically (α1)₂β1δ1ε1 in adult receptors |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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