gene 941 words KG: CLN2 2026-03-22
kind:genesection:genesstate:published
Contents

Ceroid Lipofuscinosis 2 (TPP1)

🧬 Gene Info
Gene SymbolCLN2
Full NameCeroid Lipofuscinosis 2 (TPP1)
Chromosome11p15.4
Protein TypeReceptor
FunctionIt plays critical roles in ciliary signaling, neuronal migration, and synaptic function.
Primary Expressionregions affected in Parkinson disease
UniProt IDO14773
NCBI Gene ID1200
Ensembl IDENSG00000100418
OMIM607998
GeneCardsCLN2
Human Protein AtlasCLN2
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Ataxia, Huntington, Neuroblastoma, Parkinson
Known Drugs/Compoundsrapamycin
InteractionsCALCINEURIN, ATG12, ATG10, LAMP1, LGALS3, STUB1
KG Connections212 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (2)

APOE-Dependent Autophagy Restoration
Score: 0.61
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.41

Related Analyses (2)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in