| Gene Symbol | COA6 |
| Full Name | Cytochrome c Oxidase Assembly Factor 6 |
| Chromosome | 1q23.3 |
| Function | is a small mitochondrial protein that plays a critical role in the biogenesis of cytochrome c oxidase (Complex IV), the terminal enzyme of the mitochondrial electron transport chain. |
| Subcellular Localization | the mitochondrial inner membrane. Pathogenic variants in COA6 cause severe mitochondrial disorders, including Leigh synd |
| Molecular Weight | 12 kDa |
| Amino Acids | 87 aa |
| Exons | 3 |
| GeneCards | COA6 |
| Human Protein Atlas | COA6 |
| Mitochondrial targeting peptide | First 20 amino acids form an amphipathic helix |
| Copper-binding motif | Conserved CxC sequence for copper coordination |
| Hydrophobic core | Transmembrane domain anchoring to inner membrane |
| Interaction surfaces | Regions for SCO1, SCO2, and COX1 binding |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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