| Gene Symbol | COG2 |
| Full Name | Conserved Oligomeric Golgi Complex 2 |
| Chromosome | 1q25.2 |
| Function | is a key component of the COG complex, a multi-subunit vesicle tethering apparatus essential for proper Golgi apparatus function and intracellular membrane trafficking. |
| Subcellular Localization | - Quality control of protein glycosylation
- Proper sorting of proteins to their |
| Molecular Weight | 182 kDa |
| GeneCards | COG2 |
| Human Protein Atlas | COG2 |
| Amyloid processing | Altered Golgi trafficking can affect amyloid precursor protein (APP) processing and amyloid-beta generation |
| [Tau](/proteins/tau) pathology | Impaired glycosylation may influence tau phosphorylation and aggregation |
| Synaptic dysfunction | Disrupted protein trafficking to synapses contributes to synaptic loss |
| Lysosomal function | COG2 deficiency impairs autophagosome-lysosome fusion, affecting protein clearance |
| Mitochondrial quality control | Proper trafficking is needed for mitochondrial protein import and turnover |
| Amyotrophic Lateral Sclerosis (ALS) | Disrupted protein homeostasis in motor neurons |
| Huntington's disease | Altered trafficking of mutant huntingtin protein |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |