gene 1,120 words KG: DDX46
Contents

DDX46 — DEAD-Box Helicase 46

🧬 Gene Info
Gene SymbolDDX46
Full NameDEAD-Box Helicase 46
Chromosome5q31.2
Functionis a member of the DEAD-box family of RNA helicases that functions as an essential component of the U2 small nuclear ribonucleoprotein (snRNP) complex.
Primary Expressionboth neuronal and glial cell populations, with particularly high expression in excitatory neurons [1](https://human
Molecular Weight80 kDa
Amino Acids726 aa
Exons23
UniProt ID[Q7Z417](https://www.uniprot.org/uniprot/Q7Z417)
Ensembl IDENSG00000146083
OMIM614351
GeneCardsDDX46
Human Protein AtlasDDX46
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (14)

Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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