| Gene Symbol | DHX36 |
| Full Name | DEAH-Box Helicase 36 |
| Function | is a member of the DEAH-box family of RNA helicases that recognizes and resolves G-quadruplex (G4) structures in both DNA and RNA. |
| Molecular Weight | 114 kDa |
| Ensembl ID | ENSG00000147050 |
| GeneCards | DHX36 |
| Human Protein Atlas | DHX36 |
| DEAH motif | The characteristic DEAH-box helicase core contains nine conserved motifs (Motifs I-VI, Ia, Ib, and Q motif) essential for ATP binding and hydrolysis[@bourbigot2020] |
| RecA-like domains | Two RecA-like domains form the helicase motor that couples ATP hydrolysis to nucleic acid unwinding |
| C-terminal domain | A specialized domain required for G-quadruplex recognition |
| Promoter G4 resolution | Resolves G4 structures in gene promoters to facilitate transcription initiation |
| Transcriptional elongation | Affects RNA polymerase II processivity through G4 clearance |
| Chromatin association | Associates with chromatin at G-rich regulatory elements |
| Translation initiation | Regulates 5' UTR G4-mediated translation control |
| Ribosome recruitment | Facilitates ribosomal scanning through structured 5' regions |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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