| Gene Symbol | DNAJC14 |
| Chromosome | 12q13.12 |
| Protein Type | Chaperone |
| Function | DNAJC14 is a DnaJ protein involved in ER-associated degradation (ERAD) and protein quality control. |
| Molecular Weight | 55.8 kDa |
| Amino Acids | 513 aa |
| Exons | 11 |
| GeneCards | DNAJC14 |
| Human Protein Atlas | DNAJC14 |
| Protein Aggregation Disorders | By participating in ERAD, DNAJC14 helps prevent the accumulation of aggregation-prone proteins that characterize many neurodegenerative conditions. |
| Hsp70 recruitment | The J-domain recruits and activates Hsp70 proteins |
| ATPase stimulation | DNAJC14 stimulates Hsp70 ATP hydrolysis |
| Substrate transfer | Facilitates transfer of misfolded proteins to Hsp70 |
| conformational coupling | Couples ATP hydrolysis to substrate binding |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |