| Gene Symbol | DNAJC16 |
| Protein Family | DnaJ/Hsp40 Family |
| Protein Type | Chaperone |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | Cytoplasm, Mitochondria, Endoplasmic Reticulum |
| Molecular Weight | 42 kDa |
| Amino Acids | 382 aa |
| UniProt ID | [Q9H0U4](https://www.uniprot.org/uniprot/Q9H0U4) |
| GeneCards | DNAJC16 |
| Human Protein Atlas | DNAJC16 |
| Glycine/phenylalanine-rich region | A flexible linker region between the J domain and C-terminal regions that facilitates protein-protein interactions and may contain serine phosphorylation sites. |
| C-terminal client-binding domain | Contains regions predicted to form coiled-coil structures that recognize and bind unfolded or misfolded client proteins. |
| Central nervous system | High expression in brain regions including the cerebral cortex, hippocampus, basal ganglia, and cerebellum. Expression is detected in both neuronal and glial cell populations. |
| Peripheral tissues | Moderate expression in heart, skeletal muscle, liver, and kidney. |
| Cellular localization | Cytosolic localization with potential association with membrane compartments and organelles involved in protein quality control, including the endoplasmic reticulum and mitochondria. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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