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gene 2,075 words KG: DNAJC4
Contents

DNAJC4 Gene

🧬 Gene Info
Gene SymbolDNAJC4
Chromosome11q12.1
Primary Expressionvarious tissues with highest levels in:
Molecular Weight28 kDa
Amino Acids263 aa
Exons6
Ensembl IDENSG00000110619
GeneCardsDNAJC4
Human Protein AtlasDNAJC4
Human-Mouse87% identical at the amino acid level
Human-Zebrafish72% identical
Drosophila homologDnaJ-1 with 45% identity
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Phase-Separated Organelle Targeting
Score: 0.73Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72Stress Granule Phase Separation Modulators
Score: 0.72RNA Granule Nucleation Site Modulation
Score: 0.66

Related Analyses (2)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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