| Gene Symbol | DNAQC6 |
| Full Name | DNAJ Heat Shock Protein Family (Hsp40) Member C6 |
| Chromosome | 1p31.3 |
| Protein Type | Chaperone |
| Function | The process of synaptic vesicle recycling is essential for maintaining neurotransmitter release during sustained neuronal activity, as each vesicle fusion event requires the retrieval and reuse of syn |
| Molecular Weight | 104 kDa |
| Amino Acids | 935 aa |
| Exons | 15 |
| UniProt ID | [O75037](https://www.uniprot.org/uniprot/O75037) |
| Ensembl ID | ENSG00000138231 |
| GeneCards | DNAQC6 |
| Human Protein Atlas | DNAQC6 |
| Client-Binding Region (aa 200-500) | This region contains multiple glycine-phenylalanine (GF)-rich sequences that facilitate binding to a broad range of client proteins, including components of the clathrin coat machinery. |
| Clathrin-Binding Domain (aa 600-700) | The C-terminal region contains multiple clathrin box motifs (LLDLF) that enable direct binding to the clathrin triskelion, essential for the protein's role in clathrin uncoating[^7]. |
| Phosphorylation Sites | Multiple serine/threonine phosphorylation sites regulate the protein's activity throughout the cell cycle and during synaptic activity. |
| Associated Diseases | Als, Alzheimer, Huntington, Ms, Parkinson, Parkinson's disease |
| Interactions | FBXO7, PINK1, PLA2G6, PRKN, SYNJ1, VPS13C |
| KG Connections | 137 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |