| Gene Symbol | ESCO1 |
| Full Name | Establishment of Sister Chromatid Cohesion N-Acetyltransferase 1 |
| Aliases | Page for ESCO1 |
| Protein Type | Transferase |
| Function | is a lysine acetyltransferase that modifies the SMC3 subunit of the cohesin complex, a critical step in establishing sister chromatid cohesion during DNA replication. |
| UniProt ID | Q5F2C3 |
| Ensembl ID | ENSG00000131931 |
| GeneCards | ESCO1 |
| Human Protein Atlas | ESCO1 |
| Stabilizes cohesive interactions | Locks cohesin onto chromatin to maintain sister chromatid cohesion |
| Protects from WAPL-mediated release | Prevents premature cohesin unloading |
| Establishes functional cohesin | Generates the cohesin form competent for S phase functions[@unal2008] |
| ESCO1 | Constitutively expressed, acetylates cohesin throughout the cell cycle, involved in DNA damage response |
| ESCO2 | S-phase specific, critical for replication-coupled cohesion establishment[@alomer2017] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |