| Gene Symbol | FBXO38 |
| Chromosome | 5q32 |
| Function | encodes an F-box protein that functions as a critical substrate recognition component of the SCF (Skp1-Cul1-F-box) ubiquitin ligase complex. |
| Subcellular Localization | the nucleus where it regulates transcription factor degradation |
| Molecular Weight | 80 kDa |
| Amino Acids | 714 aa |
| Exons | 11 |
| Pathways | NF-κB signaling, NF-κB |
| Ensembl ID | ENSG00000170852 |
| GeneCards | FBXO38 |
| Human Protein Atlas | FBXO38 |
| α-helical bundle | Three α-helices that create the SKP1 binding interface |
| Conserved F-box motif | The sequence LXXXLLXXN, critical for SKP1 interaction |
| Linker region | Connects F-box to the substrate recognition domain |
| LRR repeats | Typically 20-30 amino acid motifs with conserved residues |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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