gene 1,913 words KG: GAAP
Contents

GAAP Gene - Golgi Anti-Apoptotic Protein

🧬 Gene Info
Gene SymbolGAAP
Chromosome15q25.1
Protein TypeChannel
Functionencodes a multifunctional membrane protein localized primarily to the Golgi apparatus and mitochondria.
Primary Expressionneurons and glia, where it helps maintain calcium homeostasis and protects against various forms of cellular stress that contribute to neurodegenerati
Subcellular LocalizationGolgi, mitochondria
Molecular Weight~38 kDa
Amino Acids347 aa
Exons15
Ensembl IDENSG00000149691
GeneCardsGAAP
Human Protein AtlasGAAP
Transmembrane domainsSix predicted transmembrane helices
Calcium channel poreFormed by transmembrane helices
Golgi targeting signalC-terminal retention signal
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (15)

APOE-Dependent Autophagy Restoration
Score: 0.89
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57

Related Analyses (7)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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