gene 1,913 words KG: GAAP 2026-03-28
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsons
Contents

GAAP Gene - Golgi Anti-Apoptotic Protein

🧬 Gene Info
Gene SymbolGAAP
Chromosome15q25.1
Protein TypeChannel
Functionencodes a multifunctional membrane protein localized primarily to the Golgi apparatus and mitochondria.
Primary Expressionneurons and glia, where it helps maintain calcium homeostasis and protects against various forms of cellular stress that contribute to neurodegenerati
Subcellular LocalizationGolgi, mitochondria
Molecular Weight~38 kDa
Amino Acids347 aa
Exons15
Ensembl IDENSG00000149691
GeneCardsGAAP
Human Protein AtlasGAAP
Molecular weight~38 kDa
StructureMultiple transmembrane domains
Subcellular localizationGolgi, mitochondria
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (15)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (7)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in