gene 1,422 words KG: GID1
Contents

GID1 Gene

🧬 Gene Info
Gene SymbolGID1
Full NameGlucose-Induced Degradation Deficient 1 Homolog
Chromosome17p13.2
Protein TypeLigase
Functionis a critical component of the GID (CTLH) ubiquitin ligase complex, a multisubunit E3 ligase that plays essential roles in protein quality control, metabolic regulation, and cellular homeostasis.
Primary ExpressionBrain, Liver, Kidney, Pancreas
UniProt IDQ9NWV8
NCBI Gene ID84144
Ensembl IDENSG00000131791
OMIM618023
GeneCardsGID1
Human Protein AtlasGID1
Yeast (S. cerevisiae)The GID complex (also called GID complex) consists of GID1, GID2, GID3, GID4, GID5, GID7, GID8, and GID9
MammalsThe mammalian CTLH complex includes GID1 (also known as ARRDC1 or CT16), GID2, GID3, GID4, GID5, GID7, GID8, GID9, and additional subunits including ARMC8, MAEA, and RAMAC
DatabasesGeneCardsHPASTRING

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NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

APOE-Dependent Autophagy Restoration
Score: 0.89
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (5)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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