| Gene Symbol | GLI3 |
| Full Name | GLI Family Zinc Finger 3 |
| Chromosome | 7p14.1 |
| Protein Type | Transcription Factor |
| Function | encodes a 1580 amino acid zinc finger transcription factor that functions as the principal transcriptional repressor of the Hedgehog (Hh) signaling pathway. |
| Primary Expression | dorsal and intermediate regions of the neural tube, where its repressor form (GLI3R) restricts ventral cell fates |
| Molecular Weight | 83 kDa |
| Amino Acids | 1580 aa |
| Exons | 15 |
| Ensembl ID | ENSG00000106571 |
| GeneCards | GLI3 |
| Human Protein Atlas | GLI3 |
| Acrocallosal Syndrome (ACLS) | Overlaps with GCPS; features corpus callosum agenesis and intellectual disability. |
| Proteasome inhibitors | Block GLI3 processing to GLI3R; research tool for studying GLI3A-dependent transcription |
| PKA inhibitors | Prevent initiating phosphorylation required for GLI3 processing |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |