| Gene Symbol | GPR165 |
| Protein Type | Receptor |
| Function | GPR165 is classified as an adhesion GPCR (ADGR), a family of receptors characterized by extended N-terminal extracellular regions that mediate cell-cell and cell-matrix interactions. |
| Primary Expression | excitatory neurons, with lower expression in inhibitory interneurons and minimal glial expression [@striatal2020] |
| Ensembl ID | ENSG00000178209 |
| GeneCards | GPR165 |
| Human Protein Atlas | GPR165 |
| [Tau](/proteins/tau) Pathology | Given its role in neuronal signaling, GPR165 may intersect with tau phosphorylation pathways, though direct evidence is lacking. |
| Therapeutic Target Potential | The receptor's restricted expression pattern and G protein coupling make it a potential target for modulating neuronal survival pathways in AD [@rnaseq2022]. |
| Amyotrophic Lateral Sclerosis (ALS) | RNA-seq studies of spinal cord tissue from ALS patients have identified GPR165 expression changes, though the functional significance is unclear [@dopaminergic2021]. |
| Huntington's Disease | Bioinformatic analyses have suggested potential dysregulation of GPR165 in Huntington's disease models, particularly in striatal neurons [@als2022]. |
| Developmental Expression | High expression during embryonic and early postnatal development, particularly in the ventricular zone and cortical plate, suggesting roles in neurogenesis and migration [@tang2015]. |
| Cell-Type Specificity | Expressed primarily in excitatory neurons, with lower expression in inhibitory interneurons and minimal glial expression [@striatal2020]. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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