| Gene Symbol | GPR3 |
| Protein Type | Receptor |
| Function | GPR3 is a G protein-coupled receptor that is constitutively active and signals through Gs proteins to increase intracellular cAMP levels[@thathiah2009]. |
| Primary Expression | neurons and glial cells and has been shown to promote neuronal survival and protect against amyloid-beta toxicity[@thathiah2009a] |
| Pathways | MAPK signaling |
| Ensembl ID | ENSG00000170270 |
| GeneCards | GPR3 |
| Human Protein Atlas | GPR3 |
| Constitutive activity | Unlike many GPCRs, GPR3 maintains high basal activity without ligand binding |
| Gs coupling | Primary G protein coupling leads to adenylate cyclase activation and increased cAMP |
| β-arrestin pathways | Engages β-arrestin mediated signaling independent of G protein pathways |
| ERK1/2 activation | Triggers MAPK signaling cascade involved in cell survival |
| Neuronal survival | Promotes pro-survival signaling through cAMP/PKA pathway |
| Amyloid clearance | Upregulates neprilysin and other amyloid-degrading enzymes |
| Synaptic plasticity | Modulates cAMP signaling at synapses |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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