| Gene Symbol | GPR78 |
| Protein Type | Receptor |
| Function | GPR78 (GPRC5B) is a member of the G protein-coupled receptor, class C, group 5, member B. |
| Primary Expression | the brain and involved in synaptic transmission and neuronal development[@kroger2011] |
| Subcellular Localization | synapses and dendritic processes |
| Pathways | MAPK pathway, PI3K |
| Ensembl ID | ENSG00000137737 |
| GeneCards | GPR78 |
| Human Protein Atlas | GPR78 |
| Gα_i/o coupling | Primary G protein coupling inhibits adenylate cyclase |
| Gβγ signaling | Mediates downstream effectors through βγ subunits |
| ERK/MAPK pathway | Triggers cell proliferation and differentiation signals |
| PI3K/Akt pathway | Involved in cell survival and synaptic plasticity |
| Synaptic transmission | Modulates neurotransmitter release at presynaptic terminals |
| Dendritic spine formation | Regulates spine density and morphology |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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