gene 1,782 words KG: HPN 2026-03-27
kind:genesection:genesstate:published
Contents

HPN — Hepsin

🧬 Gene Info
Gene SymbolHPN
Full NameHepsin
Chromosome19q13.12
Protein TypeProtease
Functionencodes a 419-amino acid serine protease that is expressed in multiple tissues including liver, kidney, prostate, and brain.
Primary Expressionmultiple tissues including liver, kidney, prostate, and brain
Subcellular Localizationthe cell surface where it participates in extracellular matrix remodeling, growth factor activation, and protease cascad
Amino Acids419 aa
Exons6
PathwaysNF-κB
UniProt ID[P05981](https://www.uniprot.org/uniprot/P05981)
Ensembl IDENSG00000105855
GeneCardsHPN
Human Protein AtlasHPN
Gene length~7.5 kb
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (14)

Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.41
Senescent Cell Mitochondrial DNA Release
Score: 0.54
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51

Related Analyses (2)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in