| Gene Symbol | HSPB10 |
| Function | is a gene that encodes a protein belonging to the small heat shock protein family. |
| Molecular Weight | 30 kDa |
| Amino Acids | 341 aa |
| Ensembl ID | ENSG00000147133 |
| GeneCards | HSPB10 |
| Human Protein Atlas | HSPB10 |
| Sperm Outer Dense Fibers | The protein is a major component of the outer dense fibers (ODFs) of the sperm flagellum, which are essential for protecting the sperm axoneme during transit through the female reproductive tract [2] |
| Male Fertility | ODF1 is crucial for normal sperm motility and male fertility; mutations can cause asthenozoospermia (reduced sperm motility) [3] |
| Chaperone Activity | Like other sHSPs, HSPB10 may function as a molecular chaperone, preventing protein aggregation under stress conditions [4] |
| Testis | Highest expression in testis, specifically in spermatids during spermiogenesis |
| Sperm | Present in the sperm flagellum as a structural component |
| Other Tissues | Very low or undetectable expression in most somatic tissues, including brain |
| Protein Quality Control | sHSPs prevent aggregation of misfolded proteins |
| Stress Response | Upregulated under cellular stress conditions |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |