| Gene Symbol | HTR2B |
| Chromosome | 2q36.3 |
| Protein Type | Receptor |
| Function | The serotonin 2B receptor (5-HT2B) is a G protein-coupled receptor that primarily couples to Gq proteins, activating phospholipase C and leading to increased intracellular calcium. |
| Primary Expression | the cortex, hippocampus, and basal ganglia |
| Amino Acids | 481 aa |
| Exons | 13 |
| Ensembl ID | ENSG00000180264 |
| GeneCards | HTR2B |
| Human Protein Atlas | HTR2B |
| N-terminal extracellular domain | Contains glycosylation sites |
| Seven transmembrane domains (TM1-TM7) | Form the ligand-binding pocket |
| Third intracellular loop | Contains the Gq protein coupling domain |
| C-terminal intracellular tail | Contains serine/threonine residues for phosphorylation and β-arrestin recruitment |
| Cerebral cortex | Pyramidal neurons in layers II-VI |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |