| Gene Symbol | HTR5A |
| Chromosome | 7q36.3 |
| Protein Type | G protein-coupled receptor, Family 5-HT |
| Function | is a seven-transmembrane domain GPCR that couples primarily to Gα<sub>i/o</sub> proteins, leading to inhibition of adenylate cyclase and reduced cyclic AMP (cAMP) production. |
| Subcellular Localization | - **Cerebral cortex**: Particularly layer V pyramidal neurons |
| Pathways | MAPK Pathway, PI3K |
| UniProt ID | P30939 |
| NCBI Gene ID | 3363 |
| GeneCards | HTR5A |
| Human Protein Atlas | HTR5A |
| Cerebral cortex | Particularly layer V pyramidal neurons |
| Hippocampus | CA1 and CA3 regions, dentate gyrus |
| Hypothalamus | Preoptic area and suprachiasmatic nucleus |
| Raphe nuclei | serotonergic neuron cell bodies |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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