| Gene Symbol | IFT172 |
| Full Name | Intraflagellar Transport Protein 172 |
| Chromosome | 2 |
| Function | Intraflagellar Transport Protein 172 (IFT172) is a core component of the IFT-B complex (Intraflagellar Transport complex B) that is essential for cilia and flagella assembly, maintenance, and function |
| Primary Expression | photoreceptor outer segments, where it transports opsin and other visual pigments |
| Pathways | Wnt |
| Ensembl ID | ENSG00000124608 |
| GeneCards | IFT172 |
| Human Protein Atlas | IFT172 |
| Ciliogenesis | IFT172 is required for the formation and maintenance of primary cilia, which serve as signaling centers for hedgehog (Shh), Wnt, and PDGF signaling pathways[@tayeh2022] |
| Intraflagellar transport | As part of IFT-B, IFT172 mediates anterograde transport (from basal body to ciliary tip) along microtubules |
| Hedgehog signaling | Primary cilia are essential for hedgehog signal transduction; IFT172 mutations disrupt Shh pathway activity |
| photoreceptor maintenance | IFT172 is highly expressed in photoreceptor outer segments, where it transports opsin and other visual pigments |
| Neuronal cilia function | Primary cilia on neurons regulate neurogenesis and signaling |
| Axonal growth | IFT proteins regulate microtubule dynamics in growing axons[@letteboer2021] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |