gene 1,239 words KG: IL29
Contents

IL29 Gene

🧬 Gene Info
Gene SymbolIL29
Chromosome19q13.2
Functionis a cytokine gene encoding a Type III interferon that plays crucial roles in antiviral immunity, immune modulation, and neuroinflammation.
Amino Acids200 aa
Exons5
PathwaysJAK-STAT Pathway
Ensembl IDENSG00000184916
GeneCardsIL29
Human Protein AtlasIL29
Cell TypesExpressed by neurons, microglia, and astrocytes in response to viral infection
Regional DistributionHighest expression in hippocampus, cortex, and basal ganglia
InductionRequiresPattern Recognition Receptor (PRR) signaling via RIG-I/MDA5 or TLR3
AntiviralOAS, MX, IFITM, viperin
ImmunomodulatoryPD-L1, MHC-I, IL-12 antagonist
Antiproliferativep21, p27, TRAIL
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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