gene 1,511 words KG: INPP4B
Contents

INPP4B Gene — Inositol Polyphosphate-4-Phosphatase Type II

🧬 Gene Info
Gene SymbolINPP4B
Full NameInositol Polyphosphate-4-Phosphatase Type II
Chromosome4q21.21
Protein TypePhosphatase
Functionis a lipid phosphatase belonging to the inositol polyphosphate phosphatase family.
Amino Acids656 aa
UniProt ID[Q9NRY4](https://www.uniprot.org/uniprot/Q9NRY4)
Ensembl IDENSG00000040087
OMIM607610
GeneCardsINPP4B
Human Protein AtlasINPP4B
Metal ion-dependent catalysisRequires Mg²⁺ or Mn²⁺
Active site residuesCysteine nucleophile attacks the phosphate
Substrate specificityPrefers PI(3,4)P₂ and PI(4,5)P₂
Product releaseGenerates PI(3)P or PI(4)P
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

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