| Gene Symbol | KCNJ8 |
| Full Name | KCNJ8 - Potassium Voltage-Gated Channel Subfamily J Member 8 |
| Chromosome | 12p12.1 |
| Protein Family | Inward-rectifier potassium channel family (Kir6.x) |
| Protein Type | Channel |
| Function | KCNJ8 encodes Kir6.1, the pore-forming subunit of the ATP-sensitive potassium channel (KATP channel) |
| Subcellular Localization | Plasma membrane (neurons, cardiac myocytes, smooth muscle) |
| Molecular Weight | 48 kDa |
| UniProt ID | Q15818 |
| Ensembl ID | ENSG00000130159 |
| GeneCards | KCNJ8 |
| Human Protein Atlas | KCNJ8 |
| Transmembrane Domains | Two transmembrane helices (M1 and M2) that span the neuronal membrane, creating the channel pore |
| Pore Helix (H5/P-loop) | Located between M1 and M2, contains the K+ selectivity filter with the characteristic GYG motif essential for K+ selectivity |
| N-terminus | Cytoplasmic domain containing the PIP2 binding site and ATP binding region |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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