| Gene Symbol | KCNMB2 |
| Full Name | Potassium calcium-activated channel subfamily M regulatory beta subunit 2 |
| Chromosome | 3q26.32 |
| Function | The BK channel is encoded by KCNMA1 and requires association with beta subunits for proper function |
| Primary Expression | the central nervous system where they play critical roles in neuronal excitability, neurotransmitter release, and protection against excitotoxic cell |
| UniProt ID | Q9Y5W6 |
| NCBI Gene ID | 10242 |
| Ensembl ID | ENSG00000171388 |
| GeneCards | KCNMB2 |
| Human Protein Atlas | KCNMB2 |
| Beta-2 subunit function | Modulates channel gating kinetics, increases calcium sensitivity, and targets channels to specific subcellular compartments[@orio2002] |
| Tissue-specific regulation | Beta-2 subunit expression is enriched in brain and heart tissue |
| Channel properties | BK channels have exceptionally large conductance (100-250 pS) and are activated by both membrane depolarization and intracellular calcium |
| Action potential repolarization | Rapid repolarization contributes to high-frequency firing |
| Afterhyperpolarization | Modulates the afterhyperpolarization phase |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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