| Gene Symbol | KCNMB4 |
| Protein Type | Channel |
| Function | KCNMB4 encodes a 210-amino acid auxiliary subunit that modulates BK channel (encoded by KCNMA1) function: |
| Primary Expression | inner ear hair cells |
| Subcellular Localization | mitochondria (mitoBK channels) and affect neuronal survival. beta4 subunit composition may influence this protective fun |
| Amino Acids | 210 aa |
| Ensembl ID | ENSG00000135677 |
| GeneCards | KCNMB4 |
| Human Protein Atlas | KCNMB4 |
| N-terminal Extracellular Domain | Mediates interactions with the extracellular matrix and other proteins [@jaffe2011]. |
| Transmembrane Segment | Single transmembrane helix anchoring the subunit to the membrane. |
| C-terminal Intracellular Domain | Interacts with the cytoplasmic domain of the BK alpha-subunit to modulate gating [@jaffe2011]. |
| Gating Kinetics | beta4 subunits accelerate activation and slow deactivation of BK channels [@wang2019]. |
| Calcium Sensitivity | Modifies the calcium sensitivity of the channel, shifting the activation curve [@wang2019]. |
| Voltage Dependence | Alters voltage dependence of activation [@latorre2006]. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!