| Gene Symbol | Lysine Demethylase 2A |
| Chromosome | 11q13.1 |
| Protein Type | Fe(II)/2-oxoglutarate-dependent dioxygenase |
| Function | is a histone demethylase that specifically removes methyl groups from histone H3 at lysine 36 (H3K36). |
| Primary Expression | Ubiquitous, highest in brain and testis |
| Molecular Weight | 130 kDa |
| UniProt ID | Q9Y2K2 |
| NCBI Gene ID | 22992 |
| Ensembl ID | ENSG00000107140 |
| OMIM | 605469 |
| Primary substrate | H3K36me2 (dimethylated lysine 36 on histone H3) |
| Secondary substrates | H3K36me1, H3K36me0 |
| Weak activity | H3K4me3 (trimethylated lysine 4) |
| NuRD Complex | Associates with the nucleosome remodeling and deacetylase (NuRD) complex to coordinate chromatin remodeling and transcriptional repression |
| SCF Complex | Incorporates into SCF E3 ubiquitin ligase complexes for protein turnover |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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