| Gene Symbol | KYAT3 |
| Protein Type | Enzyme |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | multiple tissues: |
| Molecular Weight | 45 kDa |
| Ensembl ID | ENSG00000135926 |
| GeneCards | KYAT3 |
| Human Protein Atlas | KYAT3 |
| Kynurenine Pathway | Catalyzes transamination of kynurenine and 3-hydroxykynurenine to produce kynurenic acid (KYNA) and xanthurenic acid[@han2018] |
| KYNA Production | Generates kynurenic acid, a neuroprotective metabolite that blocks NMDA and AMPA receptors |
| Cysteine Metabolism | Involved in the mercapturate pathway for xenobiotic detoxification |
| Tryptophan Catabolism | Participates in the major route of tryptophan degradation beyond the CNS |
| Mitochondrial Localization | Functions in the mitochondrial matrix |
| Brain | Highest expression in cerebral cortex, hippocampus, basal ganglia, and cerebellum |
| Liver | Major site of kynurenine pathway activity |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |