| Gene Symbol | MYPN |
| Aliases | Myopalladin |
| Chromosome | 10q21.3 |
| Function | encodes a critical Z-disc protein that plays essential roles in sarcomere organization, assembly, and maintenance in both skeletal and cardiac muscle. |
| Molecular Weight | 162 kDa |
| Amino Acids | 456 aa |
| Exons | 30 |
| Ensembl ID | ENSG00000138379 |
| GeneCards | MYPN |
| Human Protein Atlas | MYPN |
| Skeletal Muscle | High expression in all major skeletal muscle groups, with particularly abundant levels in type 1 (slow-twitch) fibers. |
| Cardiac Muscle | Very high expression in both ventricular and atrial myocardium, reflecting the protein's critical role in cardiac function. |
| Smooth Muscle | Low to undetectable expression in most smooth muscle populations. |
| Non-muscle Tissues | Minimal expression outside of muscle tissues, confirming its role as a muscle-specific protein. |
| Alpha-actinin binding | Myopalladin directly binds to alpha-actinin, the primary cross-linking protein at the Z-disc. This interaction is essential for forming the lattice-like structure of the Z-disc. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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