| Gene Symbol | NCOA2 |
| Function | NCOA2 is a ~175 kDa protein containing multiple functional domains that mediate protein-protein interactions: |
| Primary Expression | both neurons and glial cells, with particular enrichment in pyramidal neurons and Purkinje cells [@ncoa2003] |
| Subcellular Localization | Primarily nuclear, consistent with its role as a transcriptional coactivator. |
| Molecular Weight | 175 kDa |
| Ensembl ID | ENSG00000140396 |
| GeneCards | NCOA2 |
| Human Protein Atlas | NCOA2 |
| N-terminal Domain | Contains basic helix-loop-helix (bHLH) and PAS (PER-ARNT-SIM) domains that mediate dimerization and DNA binding [@xu1999]. |
| C-terminal Activating Domains | Three autonomous activation domains (AD1, AD2, AD3) that recruit coactivators including histone acetyltransferases (CBP/p300), histone methyltransferases, and the Mediator complex [@leo2000]. |
| LXXLL Motifs | Seven LXXLL motifs that facilitate binding to nuclear receptor AF-2 domains in a ligand-dependent manner [@mckenna2002]. |
| Estrogen Receptors (ERα, ERβ) | Critical for neuroprotection, mitochondrial function, and cognitive function [@brinton2008]. |
| Glucocorticoid Receptor (GR) | Regulates stress response and neuronal viability [@sapolsky1996]. |
| Thyroid Hormone Receptors (TRα, TRβ) | Essential for brain development and myelin maintenance [@bernal2000]. |
| Retinoid X Receptors (RXR) | Partners in nuclear receptor heterodimers that regulate gene networks involved in neuronal survival [@mangelsdorf1995]. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!