gene 2,324 words KG: NDUFAF2 2026-03-27
kind:genesection:genesstate:published
Contents

NDUFAF2 — NADH:Ubiquinone Oxidoreductase Complex Assembly Factor 2

🧬 Gene Info
Gene SymbolNDUFAF2
Full NameNADH:Ubiquinone Oxidoreductase Complex Assembly Factor 2
Chromosome5q31.1.
Protein FamilyComplex I assembly factor family
FunctionND1 Subunit Incorporation: The protein assists in the proper insertion and folding of MT-ND1, the mitochondrial-encoded core subunit of Complex I
Subcellular LocalizationMitochondrial matrix
Molecular Weight20 kDa
Amino Acids182 aa
UniProt ID[Q9H0U4](https://www.uniprot.org/uniprot/Q9H0U4)
GeneCardsNDUFAF2
Human Protein AtlasNDUFAF2
Early assembly factorsNDUFAF1, NDUFAF3, and NDUFAF4 act during the earliest stages
ND1 module assemblyNDUFAF2 functions specifically at this stage, along with other factors
Late assemblyAdditional factors complete the holoenzyme
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (2)

HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.41

Related Analyses (2)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in