| Gene Symbol | NPR1 (NPR-A, GC-A) |
| Full Name | Natriuretic Peptide Receptor 1 / Guanylate Cyclase 1 |
| Chromosome | 1q22 |
| Protein Family | Natriuretic peptide receptors (NPR1, NPR2/NPR-B, NPR3/NPR-C) |
| Protein Type | Receptor |
| Function | NPR1-mediated cGMP production regulates multiple downstream effectors |
| Primary Expression | multiple brain regions: |
| Amino Acids | 1057 aa |
| UniProt ID | P16066 |
| NCBI Gene ID | 4880 |
| Ensembl ID | ENSG00000118445 |
| OMIM | 108012 |
| Extracellular ligand-binding domain | N-terminal region that binds natriuretic peptides (ANP, BNP, CNP) with different affinities |
| Transmembrane domain | Single α-helix that anchors the receptor in the plasma membrane |
| Kinase-like domain | Intracellular domain with ATP-binding activity that regulates the guanylate cyclase domain |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!