| Gene Symbol | PDE1A |
| Full Name | Phosphodiesterase 1A |
| Function | PDE1A catalyzes the hydrolysis of |
| UniProt ID | O00408 |
| Ensembl ID | ENSG00000115252 |
| GeneCards | PDE1A |
| Human Protein Atlas | PDE1A |
| cAMP | 3',5'-cyclic adenosine monophosphate → AMP |
| cGMP | 3',5'-cyclic guanosine monophosphate → GMP |
| Calcium/Calmodulin | Direct activation when Ca²⁺ binds calmodulin, which then activates PDE1A |
| Calmodulin binding domain | N-terminal regulatory domain binds Ca²⁺-CaM |
| Phosphorylation | PKA can phosphorylate PDE1A, altering its activity |
| High expression | Cerebral cortex, hippocampus, cerebellum, basal ganglia |
| Moderate expression | Heart, skeletal muscle, kidney |
| Cellular localization | Neurons, astrocytes, vascular smooth muscle cells |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |